- Inter-faculty Studies in Bioinformatics and Systems Biology
- Bachelor's degree, first cycle programme, Computer Science
- Bachelor's degree, first cycle programme, Mathematics
- Master's degree, second cycle programme, Bioinformatics and Systems Biology
- Master's degree, second cycle programme, Computer Science
- Master's degree, second cycle programme, Mathematics
Structure of Polymers and Biopolymers 1200-STPO-OG
Synthetic and natural polymers. Isomeric properties of polymers. Statistics of a single chain molecule. Coil-globule transition for flexible chain polymers. Effects of conformational stiffness. Structural ordering in polymer liquids and polymer crystallization. Dynamics of a single chain molecule in solution - the Rouse model. Dynamics of polymer chains in concentrated solutions or melts - unusual diffusion of polymers in macromolecular systems. Reptation theory and other theories of polymer dynamics. Polypeptides and proteins. Conformational analysis. Helical structures. Secondary and tertiary structure of proteins. Molecular interactions in proteins - interactions stabilizing the three dimensional structure, hydrogen bonds, hydrophobic effects. Increasing thermal stability of proteins. Protein engineering. Sequence-structure-function, evolutionary relationships. Reversible denaturation of proteins - thermodynamics and dynamics of the process. DNA, RNA and other biopolymers. DNA and chromatin structure. Secondary and tertiary structure of RNA. Interactions between biomacromolecules. Protein assemblies. Chaperons. Protein-DNA interactions. Structure of simple viruses
Type of course
Prerequisites (description)
Course coordinators
Learning outcomes
The student can describe how proteins and nucleic acids are built, and is also able to justify what this structure results from. He can describe the interactions which at the atomic level influence the conformation of a biopolymer. Understands how the process of sequence evolution is related to the structure of proteins.
Assessment criteria
Attendance and final written test (in a classroom) / oral exam (possibly online)
Practical placement
does not concern
Bibliography
1. P. G. de Gennes, Scaling Concepts in Polymer Physics, Cornell, 1979
2. P. J. Flory, Statistical Mechanics of Chain Molecules, Interscience, 1968
3. C. Branden, J. Tooze, Introduction to Protein Structure, Garland Pub. 1991
4. P. C. Turner, A. G. McLennan, A. D. Bates, M. R. H. White, Instant Notes in Molecular Biology, Springer 1998
Additional information
Information on level of this course, year of study and semester when the course unit is delivered, types and amount of class hours - can be found in course structure diagrams of apropriate study programmes. This course is related to the following study programmes:
- Inter-faculty Studies in Bioinformatics and Systems Biology
- Bachelor's degree, first cycle programme, Computer Science
- Bachelor's degree, first cycle programme, Mathematics
- Master's degree, second cycle programme, Bioinformatics and Systems Biology
- Master's degree, second cycle programme, Computer Science
- Master's degree, second cycle programme, Mathematics
Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system: