Synthesis and Characterisation of Compounds of Pharmacological Importance B 1200-1CHMSZFBL6

KNOWLEDGE: Upon completion of the course, the student:
K_W12, K_W17, K_W18, K_W19

• has advanced knowledge of the methods and techniques of synthesis and identification of organic compounds (with particular emphasis on pharmacologically relevant and biologically active compounds) using chemical, chromatographic, spectroscopic, and diffraction techniques;
• has advanced knowledge of the structure, activity, and synthesis of drugs and understands the interdisciplinary nature of designing new drugs and drug delivery systems; has knowledge of the basics of molecular modeling;
• has advanced knowledge of the structure and operation of modern measuring instruments supporting scientific research in chemistry, biochemistry, and molecular biology;
• has advanced knowledge of the principles of occupational health and safety sufficient for work in chemical, biochemical, and molecular biology laboratories.

SKILLS: Upon completion of the course, the student:
K_U09, K_U10, K_U15, K_U16

• is able to perform the synthesis of selected organic compounds, separate mixtures of selected organic compounds, and purify the obtained components;
• is able to identify selected organic and bio-organic compounds using chemical, biochemical, molecular biology, chromatographic, and spectroscopic techniques;
• is capable of planning and conducting basic research, experiments, observations, and computer simulations in the field of chemistry, biochemistry, and molecular biology, as well as critically assessing their own results and discussing measurement errors;
• is able to design, assemble, and operate selected measuring equipment, perform measurements of selected physicochemical parameters, determine their values, and assess the reliability of the obtained results;

In particular:
- understands the importance of carefully planning an experiment, observing and controlling its progress, and keeping current laboratory notes
- can skilfully plan laboratory work and adjust the amount of activities to the working time
- can perform the synthesis of a selected organic compound and can isolate and purify the products obtained;
- can perform identification of selected organic and bioorganic compounds using appropriate chemical, chromatographic and spectroscopic techniques
- is able to acquire knowledge independently and prepare a characterization study of the compound using various sources (written and electronic) including foreign language;
- is aware of the hazards in the organic chemistry laboratory and works in accordance with the principles of occupational safety and health.

The final grade consists of partial grades on:
- completion of a step related to the isolation of a substance with biological activity and development of its characterization;
- a preliminary test for an assigned preparation;
- synthesis of an organic compound and laboratory notes;
- the characterization of the obtained compound of pharmacological significance on the basis of independently found information.

Attendance is compulsory. Students are allowed up to two excused absences, which must be made up at a later date.

- J Clayden, Organic Chemistry, Oxford University Press 2001
- A. Vogel, Preparatyka Organiczna, WNT 2006
- A. Kołodziejczyk, Naturalne związki organiczne, PWN, Warszawa 2006
- www.reaxys.com
- literature made available during the classes

Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system:

• Description of 1200-1CHMSZFBL6 in USOSweb