Synthesis and Characterisation of Compounds of Pharmacological Importance B 1200-1CHMSZFBL6

Students work individually. The first part of the course involves the isolation of a known compound with biological activity and the development of its characteristics.
Then, on the basis of literature provided by the teacher, the student will prepare a work plan and carry out a multi-step synthesis of a compound of pharmacological importance. Obtained products will be analyzed, among others, by thin layer chromatography and purified by standard laboratory techniques. The structure of the final product will be confirmed by available analytical and spectroscopic techniques. The final stage will be to develop the characteristics of the obtained compound, including information on its activity, principle of action, applications, based on independently found sources.

Main fields of studies for MISMaP

biotechnology
biology
chemistry

Type of course

elective courses

Prerequisites

Analysis of Biologically Active Compounds
Analysis of Biologically Active Compounds A - laboratory
Organic Chemistry I
Organic Chemistry II Laboratory

Prerequisites (description)

The student should have basic knowledge of organic chemistry and know basic laboratory techniques, methods of purification and identification of organic compounds. The student should have passed the subjects listed in the assumptions or equivalent subjects.

Course coordinators

Anna Zawadzka

Mode

Classroom

Learning outcomes

Upon completion of the course the student:
- understands the importance of carefully planning an experiment, observing and controlling its progress, and keeping current laboratory notes
- can skilfully plan laboratory work and adjust the amount of activities to the working time
- can perform the synthesis of a selected organic compound and can isolate and purify the products obtained;
- can perform identification of selected organic and bioorganic compounds using appropriate chemical, chromatographic and spectroscopic techniques
- is able to acquire knowledge independently and prepare a characterization study of the compound using various sources (written and electronic) including foreign language;
- is aware of the hazards in the organic chemistry laboratory and works in accordance with the principles of occupational safety and health.

Assessment criteria

The final grade consists of partial grades on:
- completion of a step related to the isolation of a substance with biological activity and development of its characterization;
- a preliminary test for an assigned preparation;
- synthesis of an organic compound and laboratory notes;
- the characterization of the obtained compound of pharmacological significance on the basis of independently found information;
- report discussion.

Bibliography

- J Clayden, Organic Chemistry, Oxford University Press 2001
- A. Vogel, Preparatyka Organiczna, WNT 2006
- A. Kołodziejczyk, Naturalne związki organiczne, PWN, Warszawa 2006
- www.reaxys.com
- literature made available during the classes

Notes

Term 2023L:

None

Term 2024L:

None

Additional information

Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system:

Description of 1200-1CHMSZFBL6 in USOSweb