Organic Chemistry II Laboratory 1200-1CHMCHO2L3
Students work individually. At the beginning of the course, basic laboratory techniques (crystallization, extraction, distillation) will be presented by the tutors. Then, students will repeat the introductory exercises individually. Before starting the synthetic work, the students pass the preliminary test, consisting of two parts: simple calculations (concentrations, conversion of concentrations, calculation of reaction yield, etc.) and the knowledge of basic laboratory techniques and principles of safe laboratory work. Then students conduct the synthesis of 6 organic compounds with increasing difficulty. Before starting each synthesis, students need to pass the test on theoretical knowledge about the classes of compounds to which the product and substrates belong (basic reactions and mechanisms). They also need to know the details of experimental procedure and safety precautions related to the particular synthesis.
By conducting the synthesis of simple organic compounds, students practically apply and consolidate their knowledge of organic chemistry, learn how to properly organize work in accordance with health and safety requirements, observe and control the course of the experiment and take laboratory notes in accordance with accepted standards.
At the end of the semester, students pass a final test on practical and theoretical knowledge of organic synthesis. It will be a written test.
Expected student workload per semester - 200 hours, including:
- attendance at laboratory classes - 120 hours
- preparation for entrance tests on chemical preparations - 30 hours
- preparation for tests on techniques and final exam - 27 hours
- preparation of reports - 20 hours
- exit exam - 3 hours
Type of course
Mode
Requirements
Prerequisites (description)
Course coordinators
Learning outcomes
KNOWLEDGE (K_W08, K_W12, K_W18, K_W19): after completing the course, the student knows and understands:
- at an advanced level, the concepts of the classification of organic compounds into classes corresponding to the types of functional groups (nomenclature, structure, chemical reactions, methods of preparation, occurrence, and application). Knows and understands the mechanisms of selected organic reactions and their stereochemical aspects.
- at an advanced level, the methods and techniques of synthesis and identification of organic compounds (with particular emphasis on compounds of pharmacological importance and biologically active compounds), using chemical, chromatographic, spectroscopic, and diffraction techniques.
- advanced knowledge of the structure and operation of modern measuring equipment supporting scientific research in chemistry, biochemistry, and molecular biology.
- advanced knowledge of occupational health and safety rules sufficient to work in a chemical, biochemical and molecular biology laboratory, as well as the ability to find information on the hazards of working with specific reagents.
SKILLS (K_U08, K_U09, K_U15, K_U16): after completing the course, the student is able to
- analyze problems in the field of organic chemistry, including investigating the mechanisms of organic reactions.
- carry out syntheses of selected organic compounds. They are able to separate mixtures of selected organic compounds and purify the obtained components.
- skillfully plan and perform basic research, experiments, observations, and computer simulations in the fields of chemistry, biochemistry, and molecular biology, as well as critically evaluate their own results and discuss measurement errors.
- design, assemble, and use selected measuring equipment, and perform measurements of selected physicochemical quantities, determine their values, and assess the reliability of the results obtained.
Assessment criteria
Requirements for passing the course:
1) Acceptance of the written reports on the basic laboratory techniques (crystallization, extraction, distillation)
2) Passing tests (with a mark) before each synthesis, individual performing of the reactions and approval with a mark of written reports. The final grade depends on overall quality of work (cleanliness and safety requirements), as well as the way of conducting laboratory notes.
3) Passing with a mark all required tests during the course:
- preliminary test consisting of two parts: calculations (percentage, molar concentration, conversion of concentrations, calculation of reaction yields, etc.) as well as OHS principles and basic laboratory techniques. Completing both parts of this test is necessary to start practical excercises. The test can be improved.
-final test on practical and theoretical knowledge about organic synthesis.
To pass tests it is required to obtain at least 60% of points (if the test consists of two parts, the student must obtain 60% of points in each part).
Conditions for passing in the correction session:
Students who did not complete all practical exercises within the deadline may do ONE exercise during the correction period. Failure to perform more than one exercise makes it impossible to pass a course.
Students who did not pass the final test may pass it in the correction session.
Attendance at classes is mandatory, TWO ABSENCES are permitted (but a synthesis of all 6 compounds must be completed).
Practical placement
Not applicable
Bibliography
Basics of organic chemistry:
1. (en) J. E. McMurry, Organic Chemistry (8th ed.), Brooks/Cole Cengage Learning, Belmont 2012 (and other editions).
2. (en) R.T. Morrison, R.N. Boyd,Organic Chemistry (6th ed.), Prentice-Hall Inc., Engelwood Cliffs 1992 (and other editions).
3. (en) J. Clayden, N. Greeves, S. Warren, P. Wothers, Organic Chemistry (2nd ed.), Oxford University Press, 2012 (and other editions).
Practical organic chemistry:
1. (pl) Misicka A., Orłowska A., Piekarska-Bartoszewicz B., Witkowska E., Podstawy preparatyki organicznej. Skrypt dla studentów II roku Wydziału Chemii UW, LIBER, Warszawa 2012 (and other editions).
2. (en) A. Vogel,Textbook of Practical Organic Chemistry (5th ed.), Longman Group UK Ltd., Harlow 1984.
3. (pl) J. Wróbel, Preparatyka i elementy syntezy organicznej, PWN, Warszawa 1983.
Additional information
Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system: