Introduction to Radiogenomics 1200-2RWRADW1M
The lecture covers the basic aspects of radiogenomics, including the basics of molecular biology, genetics, biochemistry and radiochemistry. The topics that will be discussed in detail include i.a.: structure and function of nucleic acids, causes of their mutation and mechanisms of their repair; human proteome - biosynthesis, folding, post-translational modifications, activity regulation and protein degradation; cell cycle; neoplasm; and the effect of the interaction of ionizing radiation with matter, also in the diagnostic aspect. During the lecture, methods of modeling the interaction of ionizing radiation with biological systems will be presented, as well as experimental methods of studying the effect of ionizing radiation on neoplastic and normal cells. The concept base discussed during the lecture will be used as part of the laboratory exercises "Introduction to Radiogenomics - Laboratory"
Type of course
Mode
Prerequisites (description)
Course coordinators
Learning outcomes
The student will acquire basic knowledge in the field of, i.a, structure and function of nucleic acids, the role of chromatin in the regulation of gene expression, and structure and function of proteins. The student will acquire knowledge about the methods of isolating nucleic acids and proteins from biological material, as well as the methods of their determination. The student will be able to explain the influence of ionizing radiation and chemical factors on biological material, in particular DNA. In addition, they will gain knowledge about the basic applications of ionizing radiation in the diagnosis of diseases.
Assessment criteria
Written exam assessing the student's knowledge of the material covered by the lectures.
Practical placement
Not required.
Bibliography
Exemplary literature:
"Radiomics and Radiogenomics" Ed.: Ruijiang Li, Lei Xing, Sandy Napel, Daniel L. Rubin, Taylor & Francis Inc., 2019.
Additional information
Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system: