Strategy for Organic Synthesis 1200-2BLOK1WP2

The course Strategy for Organic Synthesis gives an introduction to organic synthesis. The course consists of lecture and seminar. The lecture is divided into two main parts. First part introduces the principles of retrosynthetic analysis. Next, classic and contemporary methods of organic synthesis will be presented. The seminar is devoted to the practical planing of retrosynthesis and synthesis of simple as well as more complex natural products.
Lecture Topics:
- Retrosynthetic analysis-basic principles and nomenclature.
- An practical applications of retrosynthetic analysis for planing of multisubstituted aromatic compounds synthesis.
- The classic and contemporary methods for C-C bond formation (aldol-type condensations, Michael reaction, addition of metaloorganic compounds to carbonyl group, sulfones as C-nucleofiles, palladium catalyzed cross-couplings).
- C=C double bond formation reactions (sulfur and selenium elimination, Wittig and related reactions, Julia reaction, ring closing methatesis).
- Protecting group in organic synthesis.
- Elements of asymmetric synthesis (Sharpless epoxidation, dihydroxylation, oxyamination).
- Retrosynthetic analysis and total synthesis of complex natural products monocylin and gracilamine.