Stereochemistry 1200-1STERWL

The course covers the following subjects: molecular geometry and chemical bonding; inter- and intramolecular nonbonding interactions; basic principles of stereoelectronic effects; structure of molecules (constitution, configuration, conformation); stereoisomerism - nature of enantiomers and diastereomers; basic concepts of symmetry operations and point groups; macroscopic consequences of the symmetry and dissymmetry of molecules; relative and absolute configuration; conformational analysis; computer-assisted energy estimation and ab initio calculations; stereochemistry of alkanes; conformation of acyclic molecules; conformation of cyclic molecules; prostereoisomerism, prochirality, heterotopic ligands and faces. Stereogenic centres other than carbon atom. Chirality in molecules without the presence of chiral centre - chiral axis and chiral plane. Chirality in macromolecules. Chiroptical properties and chiroptical methods