Biostereochemistry 1200-1CHMBIOSW5

The lecture is a systematic introduction to stereochemistry of biomolecules and biomacromolecules. Intra and intermolecular interactions will be preliminarily discussed as factors affecting the shape and dynamics of molecules. Next, the lecture will cover the basic knowledge of general stereochemistry, discussing individual stereogenic elements determining the chirality of molecules and their aggregates. All concepts will be illustrated with examples from the current literature. Basic knowledge on supramolecular stereochemistry will also be introduced. Next, stereochemical issues will be discussed in relation to amino acids, peptides, proteins, nucleic acids, isoprenoids, polysaccharides and simple and complex lipids, both in terms of their static and dynamic stereochemistry. Protein dynamics research issues, both experimental and using computer modeling will also be discussed. The consequences of conformational changes in biomolecules in relation to their function in the body and in the drug design will be taken into account.