Synthesis of Drug Substances 1200-1CHJSLEW6

The lecture covers the basics of medical chemistry and presents, in the form of a multimedia presentation, the specificity of pharmaceutical substances in comparison to other chemical substances. It explains the basic linear strategy and shows why a more advanced convergent strategy is preferred in the synthesis of pharmaceutical substances. The lecture presents what this strategy is all about and what are its basic advantages over other synthetic strategies. It also presents the difference between discovery synthesis and process synthesis. The lecture will present the basic motivations and principles of creating intellectual property protection in the field of synthesis of pharmaceutical substances. Selected issues related to the diagnosis of polymorphism in pharmaceutical substances and the basic methods of identifying and producing polymorphic forms will be presented. Methods of synthesizing sulfonamides from various starting structural fragments will be presented. Synthetic methods of pharmaceutical 1,3,5- and 1,2,4-triazines will be shown. Methods of synthesizing pharmaceutical substances from the group of benzothiazoles and tetrahydrobenzothiazoles will be presented. An exemplary convergent strategy for the synthesis of pharmaceutical substances will be shown. Some modern methods used in the synthesis of pharmaceutical substances will be discussed. All the material required for the written examination, mainly based on publications and patents, will be presented in lectures and made available to participants in the form of a set of slides.