(in Polish) Molecular Oncology: Advanced Research and Diagnostic Strategies 3900-2F4ANG
The lecture series “Molecular Biology of Cancer – Modern Research and Diagnostic Methods” enables students to become acquainted with the current state of knowledge on the molecular basis of carcinogenesis and innovative methods for cancer research and treatment. The course covers topics related to cancer genetics and epigenetics, the tumor microenvironment, tumor heterogeneity, cancer stem cells, next-generation sequencing (NGS) technologies, applications of bioinformatics, and RNA-based and immuno-oncology therapies.
Students will have the opportunity to learn about advanced research techniques, including in vitro and in vivo models, as well as the role of artificial intelligence in data analysis and diagnostics. The lectures also aim to highlight the importance of personalized cancer therapy and interdisciplinary collaboration in the diagnostic and therapeutic process. Additionally, the course seeks to raise students’ awareness of the ethical and social implications arising from advances in the molecular biology of cancer.
Moreover, students will acquire and refine skills in analyzing and discussing the most recent scientific publications related to the lecture topics.
Type of course
Mode
Course coordinators
Learning outcomes
Learning Outcomes
In terms of knowledge, the student knows and understands:
1. The molecular basis of cancer transformation, including the role of oncogenes and tumor suppressor genes. (B.W13, B.W14, B.W18, C.W4, C.W7, C.W9)
2. The heterogeneity and plasticity of cancer cells and their significance in diagnostics and therapy, as well as the concept of cancer stem cells. (B.W19)
3. The tumor microenvironment and its role in disease progression, as well as potential therapeutic targets. Molecular Signaling Pathways in Cancer. (B.W25)
4. Cancer research models, including organoids and animal models used in preclinical studies. (B.W29)
5. The application of NGS technologies in molecular cancer diagnostics. (B.W26)
6. Basic epigenetic mechanisms in cancer and their use in diagnostics and therapy. (B.W13, B.W14)
7. The potential of liquid biopsy as a diagnostic tool and for therapy monitoring. (B.W29, C.W42)
8. “Omics” technologies and their role in cancer research. (B.W26, B.W29)
9. Mechanisms of action of RNA-based therapies and their application in oncology. (B.W13, B.W14, C.W42)
10. Basic principles of immuno-oncology and modern immune-based therapies. (C.W21, C.W24)
11. Molecular imaging methods and their application in cancer diagnostics. (B.W29, C.W42)
12. i 13. Development of resistance and cancer relapse, as well as ethical aspects of cancer research and their clinical implications. (B.W26, B.W29)
In terms of skills, the student can:
1. Critically analyze and interpret research results in the field of molecular cancer biology. (B.U10, B.U12)
2. Apply bioinformatics tools to the analysis of genomic and transcriptomic data. (B.U10, C.U3)
3. Evaluate the potential of liquid biopsy as a diagnostic tool and for therapy monitoring. (B.U10)
4. Discuss the mechanisms of action of RNA-based therapies and their application in oncology. (B.U10, B.U12)
5. Discuss the role of artificial intelligence in cancer diagnostics and therapy. (B.U10)
6. Use knowledge of immuno-oncology to interpret modern oncological therapies. (B.U10, C.U8)
7. Use basic “omics” technologies in cancer analysis. (B.U10)
8. Apply knowledge of epigenetics and cancer biology in the interpretation of clinical research results. (B.U10)
________________________________________In terms of social competencies, the student is ready to:
1. Critically evaluate the credibility and reliability of research results in molecular oncology.
2. Continuously update knowledge in the field of modern cancer diagnostics and therapy.
3. Engage in interdisciplinary collaboration within scientific research and clinical teams to improve cancer diagnostics and treatment.
Assessment criteria
Assessment Methods and Criteria
• Maximum number of permitted absences: 2 (lecture or seminar)
• Final course assessment will consist of preparing and leading a discussion of a scientific paper related to topics previously covered in the lectures, as well as ongoing active participation in classes.
Additional information
Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system: