Pharmacognosy 1400-228FAR
Lecture:
History of pharmacognosy since ancient time. Origin and classification of plants as well as crude drugs of plant, various types microbes (bacteria, fungi) and animal origin, use for medicine. Methods of isolation, identification and determine structure(s) of bioactive compounds. Extraction by different solvents, chromatography (HPLC, GLC, VLC, CCC, TLC), mass spectrometry (MS), nuclear magnetic resonance spectroscopy (NMR), UV/VIS and IR spectrometry.
Primary and secondary metabolism in plants (basic metabolic cycles and pathways). Occurrence, structure and biosynthesis of carbohydrates, polysaccharides, fatty acids, phospholipids, polyketides, isoprenoids (mono-, di-, tri- tetraterpenoids), phenolic compounds, alkaloids, pseudoalkaloids, antibiotics and vitamins and their therapeutic use.
Laboratory:
Isolation, purification and identification vitamins A and E, Q, polyprenol qunones, caffeine, flavonoids, sterols, triterpenic saponins ,triterpenic acids, lycopene, phosphocholine, rutoside, lobeline, berberine, cardenolides or anthocyanins from different plant material. Using methods: extraction by different solvents, chromatography (HPLC, GLC, CC, TLC), mass spectrometry (MS), UV/VIS spectrometry.
Type of course
Mode
Course coordinators
Learning outcomes
Has knowledge of general and detailed pharmacognosy its role in medicine.
Knows : (i) characteristics and compartmentation of metabolic processes in plant cells and their interaction and regulation, (ii) a large diversity of functions of plant metabolites in cell, plant and environmental, (iii) the application of plant natural products in medicine and in food and cosmetic i
Has knowledge of a modern language (Polish or English) sufficient for using electronic resources and scientific literature devoted to broadly defined pharmacognosy.
Appreciates the importance of pharmacognosy for medicine.
Is careful and critical when acquiring and interpreting knowledge in pharmacognosy.
Understands the need for informing the public about lates achievements in pharmacognosy and is able to pass this knowledge in an intelligible way.
Assessment criteria
Exam in a written form after a positive grade of the laboratory part.
Practical placement
No
Bibliography
Wagner H., Wiesenauer M., Phytotherapie. G. Fischer Verl., Stuttgart 1995.
Heldt H.W., Plant Biochemistry. Elsevier Acad. Press, San Diego California 2005.
Bisset N.G., Wichtl J.D., Herbal Drugs and Phytopharmaceuticals. CRC Press, Boca Raton 2001.
Harborne B., Baster M. (Ed.) Phytochemical Dictionary. Taylor – Francis, Bristol 1993.
Ikeda T., Yokomizo K., Okawa M., Tsuchihashi R., Kinjo J., Nohara T., Uyeda M. (2005) Anti-herpes virus type 1 activity of oleanane-type triterpenoids. Biol. Pharm. Bull. 28, 1779-1781.
Cody V., Middleton E., Harborne J.B., Beretz A., Plant Flavonoids in Bioplogy and Medicine. Acad. Press, New York 1988.
Southon I.W., Buckingham J., Dictionary of Alkaloids. Chapman Hall, ,London 1989.
Heldt H.W., Plant Biochemistry, Elsevier Academic Press San Diego California 2005
Fraga C.G. (Ed.) Plant Phenolics and Human Health, Biochemistry, Nutrition and Pharmacology, Wiley, New Jersey 2010.
Additional information
Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system: