Immunology 1400-216IMM
Lectures represent an extension of problems discussed in “Basic immunology”. It begins with an introduction related to functioning of innate and adaptive immunity and proceed to advances in basic and clinical immunology.
Teaching topics are:
1. Introduction part 1: mechanisms of innate immunity
2. Introduction part 2: mechanisms of adaptive immunity
3. Genetic basis of immune responses
4. Regulation of immunity by antigen-presenting cells, antigens and antibodies.
5. Mechanisms of immunological tolerance
6. Interactions of the immune and neuroendocrine systems.
7. Mechanism of defense against pathogens and evasive mechanism of pathogens.
8. Mechanisms of overexpressed activity of the immune system in hypersensitivity and autoimmunity.
9. Immunodeficiences – types of diseases and causative agents.
10. Immune response to alloantigens – introduction to transplantology.
11. Immune response in pregnancy – foetus/mother interactions.
12. Immune response against cancer cells.
13. Immunomodulation: immunosuppressive drugs, gene therapy, immune cells in various disease therapy, vaccines.
14. Antigen-independent function of immune system in physiological and sterile conditions.
15. The greatest discoveries in immunology.
Laboratory is a practical part of the course focusing to immune system anatomy, functions, experimental models and methods used in laboratory practice. Related topics are:
1. Anatomy of the mammals immune system.
2. Cells of innate and adaptive immunity – morphology and functions.
3. Methods of leukocytes isolation – part 1.
4. Methods of leukocytes isolation – part 2.
5. Phenotypic analysis of immune cells by flow cytometry.
6. Activation and effector functions of innate immune cells. Examination of phagocytic activity of macrophages.
7. Activation and effector functions of adaptive immune cells. I. Proliferation activity of T and B lymphocytes.
8. Activation and effector functions of adaptive immune cells. II. Methods of immunoglobulins detection.
9. Activation and effector functions of adaptive immune cells. III. Detection of cytokine synthesis.
10. Serological reactions in clinics.
11. Animal experimental models and established cell lines in immunology research.
12. Overwiev of advanced techniques in experimental immunology.
Type of course
Mode
Prerequisites
Prerequisites (description)
Course coordinators
Term 2023L: | Term 2024L: |
Learning outcomes
Having completed the course and the lab the student will achieve particular knowledge, skills and social competencies.
KNOWLEDGE
1.Has broad knowledge in the fields of mechanisms of innate and adaptive immunity, their regulation and methods used to identify the phenotype and functions of immune cells. (K_W05)
2. Has up-to-date knowledge in recent original publications, scientific terminology and definitions used to explain functions and role of the immune system. (K_W06)
3. Is able to identify the development in the field of immunology and discriminate the theoretical and applicative value of particular discovery. (K_W18)
4. Has the knowledge of modern techniques used in experimental immunology. (K_W12)
5. Is familiar with the rules of research planning, up-to-date techniques of data collection and the use of various research tools in experimental immunology. (K_W10)
6. Is familiar with the rules of research planning on laboratory animals and cell lines. (K_W13)
SKILLS
1. Has knowledge of a modern language (Polish or English) sufficient for using electronic resources and scientific literature in the field of immunology and is able to select information basing on its scientific value. (K_U03, K_U04)
2. Is able to elaborate a scientific problem basing on selected scientific literature. (K_U08)
3. Is able to study on his/her own and focus on the study area. (K_U13)
4. Uses broadly understood advanced techniques in research of immune response mechanisms in mammals. (K_U01)
5. Is able to plan experiments, draw proper conclusions and interpretation of research results based on the obtained data under control of supervisor. (K_U07)
SOCIAL COMPETENCIES
1. Understands the need for continuous learning and shows a positive kind of criticism related to scientific news (K_K07)
2. Understands the need for informing the public about latest achievements in immunology with special attention to human immunity. (K_K02)
3. Can convince other people to the need for developing researches in immunology for theoretical and practical purpose. (K_K03)
4. Is responsible for the assessment of the risks associated with experiments on laboratory animals and understands the necessity of their involvement in immunological research. (K_K06)
5. Is responsible for the research which has been assigned to him/her, for his/her own laboratory work and other people’s work. (K_K04)
6. Is responsible for the organization of safety conditions for conducted experiments and is able to evaluate the level of hazard resulting from experimental techniques. (K_K08)
Assessment criteria
Exam in a written form after obtaining a positive grade of the laboratory part.
Practical placement
Not applicable.
Bibliography
1. Kuby Immunology. Kindt T.J., Goldsby R.A., Osborne B.A., W.H.Freeman and Company, New York 2007.
2. Cellular and Molecular Immunology. Abbas A.K., Lichtman A.H., Sanders 2006.
3. Janeway’s Immunobiology. Murphy K., Travers P., Walport M.Garland Science, New York 2008.
4. Immunology. Luttmann W., Bratke K., Kupper M., Myrtek D. Elsevier 2006.
5. Essentials of Clinical Immunology. Chapel H., Haeney M., Misbah S., Snowden N. Blackwell Science 2001.
Additional information
Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system: