Chemometry and research quality control 1200-SPORSchos

The updated edition of standard 17025 in relation to its previous version introduces significant changes to the management system of laboratories. One of them is the implementation of a process approach in the work of a research laboratory. Among the 11 identified processes in the work of a research laboratory, the process of selection, verification and validation of methods and the related process of calculating measurement uncertainty are of key importance. The main goal of the course is to discuss the process of verification or validation of the measurement procedure. This includes:
statistical methods used in the validation of research methods
• Confirmation of the suitability of a method for a specific application: confirmation of a own procedure or confirmation / verification of a standardized method
• validation characteristics of instrumental methods:
o linear and non-linear calibration curve with or without the uncertainty of both correlated variables, estimation of the uncertainty of the calibration curve, assessment of linearity
o testing the precision of the method under the conditions of within-laboratory repeatability and reproducibility
o analysis of method load, evaluation of method correctness
o limit of detection and quantification
• examples from the practice of analytical and physicochemical laboratories using the e-stat service