Synthesis of molecular receptors and their interaction with ions 1200-PROJ51
The aim of the project is to become acquainted with the developed molecular receptors and to design a new effective receptor capable of selectively binding inorganic salts and to examine its complex-forming properties by independently performing a number of experiments, describing them and drawing conclusions from them.
It will be necessary to
- Getting acquainted with literature data on existing domains binding anions and cations;
- determination of analytical methods to investigate the binding properties of molecular receptors,
- critical assessment of literature data,
- design and synthesis of organic compounds,
- refinement of synthesis conditions;
- familiarization and application of methods for separating the post-reaction mixture (column chromatography, thin layer chromatography (TLC));
- chemical analysis of an organic compounds;
- analysis of spectroscopic data in the identification of the obtained compounds (1H NMR, 13C NMR, 19F NMR and 2D spectra) and mass spectroscopy (MS) spectra.
- learning about titration methods under UV-vis control and fluorimetry,
- interpretation of the recorded spectra and, based on the obtained results, determination of the stability constant of the receptor-salt complex;
An important element of the project will be conducting independent experiments and preparing appropriate solutions for analysis. Preparing a report, assessing and discussing the results obtained will be the basis for achieving the project's goal.
Type of course
Prerequisites (description)
Learning outcomes
After completing the course/ the project, the student should:
- be able to apply the learned laws of chemistry in the analysis of selected chemical problems;
- know the theoretical basis of methods for identifying organic compounds;
- have extended knowledge about the formation of non-covalent complexes of molecular receptors with inorganic salts;
- know experimental methods used to separate components of mixtures of organic compounds;
- be able to select analysis conditions for thin-layer and column chromatography;
- be able to identify organic compounds based on 1H NMR, 13C NMR, 19F NMR and 2D spectra and mass spectroscopy (MS) spectra;
- learn the method of titration of supramolecular complexes under UV-vis control and fluorimetry;
- be able to determine the stability constants of supramolecular complexes and interpret UV-vis and emission spectra;
- have the ability to organize one's work, analyze the results obtained and critically assess the degree of project implementation.
Assessment criteria
The basis for the final assessment will be a report prepared on the analysis of data received during the project and an oral defense of the proposed procedure.
The student's activity during contact work and his/her preparation for laboratory classes (conversation about the research conducted on a given day) will be taken into account.
Bibliography
1. R.T. Morrison, R.N. Boyd – Organic Chemistry, Prentice Hall, 1992.
2. R. M. Silverstein, F. X. Webster and D. J. Kiemle, “Spectrometric Identification of Organic Compounds,” 7th Edition, John Wiley & Sons, 2005.
3. F. Wehrli, T. Wirthlin - Interpretation of Carbon-13 NMR Spectra, John Wiley & Sons, 1976.
4. Murray, R.K., Granner, D.K., Mayes, P.A. and Rodwell, V.W. (2003) Harper’s Illustrated Biochemistry. Lange Medical Books/ McGraw Hill, New York.
5. Jonathan W. Steed, Jerry L. Atwood, Supramolecular Chemistry 3e, John Wiley and Sons Ltd, 2022.
6. Joan Ribas Gispert, Coordination Chemistry, Wiley-VCH Verlag GmbH, 2008.
Professional literature indicated by the project coordinator and independently collected by students.