Synthesis of molecular receptors and their interaction with ions 1200-PROJ51
The aim of the project is to become acquainted with the developed molecular receptors and to design a new effective receptor capable of selectively binding inorganic salts and to examine its complex-forming properties by independently performing a number of experiments, describing them and drawing conclusions from them.
It will be necessary to
- Getting acquainted with literature data on existing domains binding anions and cations;
- determination of analytical methods to investigate the binding properties of molecular receptors,
- critical assessment of literature data,
- design and synthesis of organic compounds,
- refinement of synthesis conditions;
- familiarization and application of methods for separating the post-reaction mixture (column chromatography, thin layer chromatography (TLC));
- chemical analysis of an organic compounds;
- analysis of spectroscopic data in the identification of the obtained compounds (1H NMR, 13C NMR, 19F NMR and 2D spectra) and mass spectroscopy (MS) spectra.
- learning about titration methods under UV-vis control and fluorimetry,
- interpretation of the recorded spectra and, based on the obtained results, determination of the stability constant of the receptor-salt complex;
An important element of the project will be conducting independent experiments and preparing appropriate solutions for analysis. Preparing a report, assessing and discussing the results obtained will be the basis for achieving the project's goal.
Type of course
Prerequisites (description)
Course coordinators
Learning outcomes
After completing the course/ the project, the student should:
- be able to apply the learned laws of chemistry in the analysis of selected chemical problems;
- know the theoretical basis of methods for identifying organic compounds;
- have extended knowledge about the formation of non-covalent complexes of molecular receptors with inorganic salts;
- know experimental methods used to separate components of mixtures of organic compounds;
- be able to select analysis conditions for thin-layer and column chromatography;
- be able to identify organic compounds based on 1H NMR, 13C NMR, 19F NMR and 2D spectra and mass spectroscopy (MS) spectra;
- learn the method of titration of supramolecular complexes under UV-vis control and fluorimetry;
- be able to determine the stability constants of supramolecular complexes and interpret UV-vis and emission spectra;
- have the ability to organize one's work, analyze the results obtained and critically assess the degree of project implementation.
Assessment criteria
The basis for the final assessment will be a report prepared on the analysis of data received during the project and an oral defense of the proposed procedure.
The student's activity during contact work and his/her preparation for laboratory classes (conversation about the research conducted on a given day) will be taken into account.
Bibliography
1. R.T. Morrison, R.N. Boyd – Organic Chemistry, Prentice Hall, 1992.
2. R. M. Silverstein, F. X. Webster and D. J. Kiemle, “Spectrometric Identification of Organic Compounds,” 7th Edition, John Wiley & Sons, 2005.
3. F. Wehrli, T. Wirthlin - Interpretation of Carbon-13 NMR Spectra, John Wiley & Sons, 1976.
4. Murray, R.K., Granner, D.K., Mayes, P.A. and Rodwell, V.W. (2003) Harper’s Illustrated Biochemistry. Lange Medical Books/ McGraw Hill, New York.
5. Jonathan W. Steed, Jerry L. Atwood, Supramolecular Chemistry 3e, John Wiley and Sons Ltd, 2022.
6. Joan Ribas Gispert, Coordination Chemistry, Wiley-VCH Verlag GmbH, 2008.
Professional literature indicated by the project coordinator and independently collected by students.
Additional information
Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system: