Free Radicals in Chemistry and Biochemistry 1200-2SPEC152M
History of organic free radical chemistry. Structure of free radicals. Carbon-, oxygen-, nitrogen-, and sulfur-centered free radicals. Production of free radicals in laboratory. Detection of free radicals. Stability and reactivity. Physical organic chemistry methods used for studying of free radical reaction mechanisms: thermodynamics, thermochemistry, and chemical kinetics. Kinetic Isotope Effects. Oxidation and reduction mediated by free radicals.
Gaseous and liquid phase processes. Solvation of radicals and the Cage Effect. Kinetic Solvent Effect.
Examples of decomposition, fragmentation, cyclization, transformation and recombination processes. Free radicals in organic synthesis. Atmospheric processes mediated by free radicals. Toxicology of free radicals – a few cases of reactions in living organisms. Metal ions as precursors of free radicals. Oxidative stress. Examples of diseases caused by free radicals. Free radical theory of aging.
Type of course
Prerequisites (description)
Course coordinators
Mode
Learning outcomes
The students attending the course will be able to present essential knowledge about the structure of organic free radicals, their physical and chemical properties, the experimental methods of studies of free radical reaction kinetics, and the role of free radicals in a number of chemical and biochemical processes. The aim of the course is to prepare the students to read scientific literature on free radicals as well as to conduct the research projects in this field.
Assessment criteria
examination, or work (presentation and discussion) , the final assessment put on the basis of the score
Practical placement
N/A
Bibliography
- C. Walling, Free Radicals in Solution, Wiley, New York, 1957
- J. K. Kochi (Ed.): Free Radicals,J. Wiley & Sons, New York, 1973
- J. Perkins: Radical Chemistry, Ellis Horwood, London, 1994
W. A. Pryor: Free Radicals, McGraw-Hill Book Company 1966
R. Olinescu, T. Smith: Free Radical In Medicine, Nova Science Publisher, New York 2002
N. S. Isaacs: Physical Organic Chemistry, Longman Sci., Essex, 1995
D. C. Nonhebel, J. C. Walton: Free-Radical Chemistry, Cambridge University Press, 1974
J. T. Hynes, Klinman J.P., Limbach H.-H., Showen R. L. (Eds): Hydrogen Transfer Reactions, vol. I-IV, Willey- VCH, Weinheim, 2007
D. I. Davies, M. J. Parrott: Free Radicals in organic synthesis, Springer-Verlag, Berlin, 1978
Notes
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Term 2023L:
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