Synthesis of Labeled Compounds and their Application in Organic Chemistry, Biochemistry and Medicine 1200-2SPEC132M

The lecture is devoted to issues related to the synthesis of labeled compounds and their application in organic chemistry, biochemistry and medicine.
The lecture covers the following topics:
- specific and non-specific methods for the synthesis of chemical compounds labeled with stable (2-H) and radioactive (3-H, 11-C, 14-C, 13-N, 15-O, 18-F, 76-Br, 131-I) isotopes,
- radionuclides and radiopharmaceuticals used in medicine,
- positron emission tomography (PET),
- examination of chemical reaction mechanisms by isotope methods.

Type of course

obligatory courses

Mode

Classroom

Prerequisites (description)

The student before starting the course should: - demonstrate knowledge of the basics of knowledge in the field of organic chemistry and nuclear chemistry, - demonstrate the ability to search and use textbook literature.

Course coordinators

Elżbieta Winnicka

Learning outcomes

After completing the course of this subject, the student should demonstrate knowledge of:
- chemical, enzymatic synthesis and isotope exchange of stable and radioactive isotope compounds and the use of these compounds as radiopharmaceuticals in medicine,
- positron emission tomography (PET) activities and applications in nuclear medicine,
- investigation of chemical reaction mechanisms by the kinetic and solvent isotope effects method (KIE and SIE).

Assessment criteria

Exam - test I and test II.
0% - 50% 2
51% - 60% 3
61% - 70% 3.5
71% - 80% 4
81% - 90% 4.5
91% - 100% 5

Practical placement

None.

Bibliography

Synthesis and Application of Isotopically Labelled Compounds, D.C. Dean, C.N.Filer, K.E. McCarthy editors, Vol.8, John Wiley and Sons, Ltd, England, 2004.

Additional information

Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system:

Description of 1200-2SPEC132M in USOSweb