Fundamentals of Asymetric Transformations 1200-2SPEC112M
This course is designed to survey the fundamental principles of molecular asymmetry in biological and synthetic organic chemistry. Topics include properties of stereoisomers and properties of racemates and their enantiomeric components. Stereoisomers discrimination in achiral and chiral envirionment. Biodiscrimination. Enzymatic reactions. Origin of enantiomeric homogenity in nature and the origin of life. Concepts of non-conservating of parity in modern physics and its consequences in chemistry. Absolute asymmetric synthesis. Asymmetric transformations of racemates. Resolution of stereoisomers. Enantiomeric and diastereomeric enrichment and kinetic resolution. Racemization mechanisms and applications. Basic concepts of stereoselective synthesis (Hammond postulate and Curtin-Hammett principle). Models for chirality transfer. Thermodynamic and stereoelectronic effects in stereodifferentiation. Selected examples of stereoselective synthesis
Type of course
Course coordinators
Learning outcomes
Good knowledge on stereoisomer recognition in modern chemistry and biochemistry.
Assessment criteria
Egzamination in written or oral form.
Practical placement
Not applicable.
Bibliography
E.L. Eliel, S.H. Wilen, "Stereochemistry of Organic Compounds", John Wiley & Sons, New York, 1994
M. J. T. Robinson, Organic Stereochemistry, Oxford University Press, Oxford, 2000
Additional information
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