Applications of Microwaves in Organic Synthesis 1200-2MON16Z
The goal of the lecture is introducing microwaves as new, ecological energy source in organic synthesis. Application of chemical processes that restrict usage and creation of hazardous substances and limit energy consumption by greatly increaing reaction speed is in agreement with Green Chemistry rules. The lecture presents examples of application of microwave technique in organic synthesis, with choice of conditions (solvent, solvent-free syntheses, application of ionic liquid, solid support or modern catalysts).
Lecture subjects: History of application of mcirowaves in organic chemistry. Theoratical bases for interaction between microwaves and matter. Mechanisms of microwave heating. Choice of solvent in microwave synthesis. Application of ionic liquids. Solvent-free syntheses. Pressurized syntheses. Microwave effect related to reaction mechanism. Examples of microwave assisted syntheses. Application of microwaves in biochemical and radio-chemical synthesis. Apparatus for microwave synthesis. Starting with microwave synthesis: choosing conditions - optimization. Biological effects of microwaves.
Type of course
Mode
Prerequisites (description)
Learning outcomes
After completing the course student
- knows theoretical basics of microwave heating,
- knows examples of application of microwaves for synthesis of various organic compounds, pharmaceuticals and radiopharmaceuticals,
- is able to choose conditions for specific synthesis.
Assessment criteria
Written final test.
Practical placement
not applicable
Bibliography
Microwave Assisted Organic Synthesis, Blackwell Publishing, 2005.
Kappe C.O., Stadler A. Microwaves in Organic and Medicinal Chemistry, Wiley, 2007.
Hayes B.L., Microwave Synthesis, CEM Publishing, 2002.