Specialization Laboratory 1200-2CHMPRSP1M
The course acquaints the student with the theoretical foundations and practical use of research and analytical techniques as well as elements of organic synthesis that may be useful during the implementation of the diploma thesis. The topics of the specialization exercises are related to the scope of research work carried out in the didactic units of ZChOiTCh and ZChNiA. As part of the specialization laboratory, students perform fourteen exercises on the following topics:
- Solid Support Peptide Synthesis (SPPS)
- Analysis of residual solvents in drug active ingredients by capillary chromatography
- Click chemistry: synthesis of a fluorescently labeled compound and its properties.
- Synthesis of a 5' end mRNA analogue and study of its inhibitory properties in rabbit reticulocyte extract.
- Synthesis and physicochemical characterization of drug delivery systems based on surface-modified gold nanoparticles.
- Use of infrared spectroscopy for structural studies of model cell membranes.
- In search for new pyrazinamide cocrystals.
- Iron oxide nanoparticles - synthesis, characterization and application in magnetic hyperthermia.
- Clinical analysis by advanced spectrometric techniques: X-ray fluorescence (XRF), inductively coupled plasma ionization mass spectrometry (ICP-MS).
- Stability analysis of active substances in drugs / dietary supplements using liquid chromatography.
- Microscopic imaging of soft structures
Main fields of studies for MISMaP
Type of course
Mode
Prerequisites (description)
Course coordinators
Learning outcomes
After completing the learning process, the student will be able to:
- use various research and analytical techniques;
- prepare the apparatus for synthesis and perform the organic synthesis
- use the selected measuring equipment;
- formulate a research hypothesis and verify it;
- carry out data analysis using IT techniques;
- prepare a scientific report;
- present and discuss the results of the conducted experiments and draw appropriate conclusions;
- search for literature on a given issue.
Assessment criteria
The basis for passing the classes of the Laboratory is an execution of all exercises, grading each entry / exit tests and grading each report.
The final grade from the studio results from the weighted average (WA) which is the sum of the arithmetic mean of all entry / exit tests (AmT) with a weight of 0.7 and the arithmetic mean of all reports (AmR) with a weight of 0.3, according to the following formula: WA = 0.7 × AmT + 0.3 × AmR
Practical placement
Not applicable.
Bibliography
Literature appropriate to the topic of the exercise, given by the teacher.
Additional information
Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system: