Advanced Synthesis of Pharmaceutical Substances 1200-2CHMMO1W3
The subject of the lecture is to present the outline of modern medical chemistry of low molecular weight active substances of drugs from the group of nucleosides with activity against the SARS-CoV-2 virus. In the lecture block, methods of designing and obtaining such antiviral nucleosides as remdesivir, molnupiravir, favipiravir, galidesivir, Paxlovid and lufotrelvir will be presented. The study of biological activity of antiviral substances and optimization of their structure will be presented. The mechanisms of the antiviral activity of nucleoside compounds will be elucidated. The concept of a prodrug (PROTIDE) will be presented. The lecture is illustrated with materials from publications from leading research centers in generally available Open Access journals (no textbooks are available for the lecture). All the lecture material will be presented on slides and short videos and entirely available to the lecture attendees.
Type of course
Mode
Course coordinators
Learning outcomes
Understanding modern methods of advanced medical chemistry on the example of designing and obtaining active substances of drugs against the SARS-CoV-2 virus. Acquiring the ability to perform retrosynthetic analysis and design a general scheme for the synthesis of antiviral nucleosides. Understanding the mechanisms of action of antiviral drugs at the molecular level.
Assessment criteria
Final written exam on the lecture material.
Answering 15 questions within 1.5 hours. in the form of a description or a scheme of synthesis.
Bibliography
Open Access 2-3 publications from the leading scientific journals presented at each lecture.
Additional information
Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system: