Strategies in Organic Synthesis 1200-2CHMMO1W2
The course Strategy for Organic Synthesis gives an introduction to organic synthesis. The course consists of lecture and seminar. The lecture is divided into two main parts. First part introduces the principles of retrosynthetic analysis. Next, classic and contemporary methods of organic synthesis will be presented. The seminar is devoted to the practical planing of retrosynthesis and synthesis of simple as well as more complex natural products.
Lecture Topics:
- Retrosynthetic analysis-basic principles and nomenclature.
- An practical applications of retrosynthetic analysis for planing of multisubstituted aromatic compounds synthesis.
- The classic and contemporary methods for C-C bond formation (aldol-type condensations, Michael reaction, addition of metaloorganic compounds to carbonyl group, sulfones as C-nucleofiles, palladium catalyzed cross-couplings).
- C=C double bond formation reactions (sulfur and selenium elimination, Wittig and related reactions, Julia reaction, ring closing methatesis).
- Protecting group in organic synthesis.
- Retrosynthetic analysis and total synthesis of complex natural products monocylin and/or gracilamine.
Main fields of studies for MISMaP
Type of course
Mode
Prerequisites (description)
Course coordinators
Learning outcomes
K_W04 – The student has knowledge of modern methods for the synthesis of complex organic compounds, including those with therapeutic activity, utilizing both classical and recent achievements in organic synthesis.
K_U24 – The student is able to design the synthesis of complex organic compounds, including those with therapeutic activity.
K_K05 – The student is able to assess the scope of their own knowledge and skills and is committed to improving their professional and personal competences.
Assessment criteria
The comprehensive written exam.
Total student workload: 100 hours, including:
- participation in lectures – 30 hours,
- participation in proseminars – 15 hours,
- consultations with the instructor (lectures and proseminars) – 15 hours,
- preparation for proseminar – 15 hours,
- preparation for the final exam – 25 hours.
Practical placement
No
Bibliography
- Clayden J., Greeves N., Warren S., Wothers P., Chemia Organiczna, Wydawnictwa Naukowo-Techniczne, 2009.
- McMurry J., Chemia Organiczna, Wydawnictwo Naukowe PWN, 2007
- J. Skarżewski, Wprowadzenie do Syntezy Organicznej, Wydawnictwo Naukowe PWN, 1999.
- Stuart Warren, Paul Wyatt, Organic Synthesis: The Disconnection Approach, Wiley, 2008
Additional information
Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system: