Chemistry of Peptides and Proteins 1200-2BLOK2W2
The following issues will be presented during the course:
1. Historical outline of peptide synthesis
2. Natural amino acids: occurrence and properties
3. Structure and biological acitivity of selected biologically active peptides
4. Peptide synthesis: protecting groups used in peptide chemistry (amino, carboxy , hydroxylic, or tiol function)
5. Peptides synthesis: condensation reaction (methods and reactants)
6. Peptide synthesis in solution and on the polymeric support
7. Problem of racemisation
8. Peptide purification and analysis (HPLC, MS, 2D NMR)
9. Structure-activity relationship of biologically active peptides
10. Drug design: From natural peptides to drugs (peptidomimetics)
11. Peptide drugs
12. Combinatorial peptide synthesis
13. Proteins: classification, levels of protein structure, receptors
14. Application of peptides and proteins in physicochemical research
Main fields of studies for MISMaP
Type of course
Mode
Prerequisites (description)
Course coordinators
Learning outcomes
After finishing this course student should be familiar with the basic concept of peptide synthesis, including stategy and tactic of peptide synthesis for different applications of synthetic peptides.
It should also have the ability to define common research objectives of those involved in the research of biological, biochemical and physicochemical properties of peptides and proteins.
Assessment criteria
Exam.
Practical placement
Does not concern
Bibliography
Peptides: chemistry and biology, Sewald N., Jakubke HD., Viley-VCH, 2002
Naturalne związki organiczne, Kołodziejczyk A., PWN, 2005
Aminokwasy, peptydy i białka, Jakubke HD., Jeschkeit H., PWN, 1989
Introduction to Medicinal Chemistry, Patrick G. Oxford University Press 2005
Additional information
Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system: