The synthesis of the biomolecules - laboratory 1200-2BLOK2L2

Students will work individually.
The first part of laboratory class will focus on the isolation of a compound with known biological activity from plant material.
The aim of the secend part of the course is to familiarize the students with the modern techniques used in the synthetic laboratory. During the curse, the student will perform a multi-step synthesis of the organic compound of the potentiall biological importance (e.g. melatonin, beta-lactam antibiotics).
At the beginning, the student will be informed of its assigned synthetic goal (student will know the structure of the compound, that should be obtained during the laborotory). His task will be to gather relevant literature using the available databases. Then the student, in cooperation with the lecturer, will prepare the research plan and will start the synthesis.

Main fields of studies for MISMaP

chemistry

Type of course

obligatory courses

Prerequisites (description)

Before the classes student should: - have a basic knowledge of organic chemistry; - possess the ability to work independently in the laboratory synthetic; - know the basic techniques of purification and identification of organic compounds, in particular distillation, extraction, crystallization, column chromatography, thin layer chromatography; - know the health and safety rules for the chemistry lab - know the basic techniques used to establish / confirm the structure of organic compounds (1H NMR, 13C NMR, MS etc.).

Course coordinators

Joanna Matraszek

Mode

Classroom

Learning outcomes

After completing the course, "The synthesis of the biomolecules - laboratory" the student is able to:
- plan the synthesis of the organic compound with finding relevant literature;
- choose the best synthetic pathway of many available in literature;
- plan the laboratory work;
- use gained knowledge to efficiently carry out a multi-step synthesis of the organic compound;
- independently acquire informations and prepare a study on the characteristics of the relationship using various sources, including foreign language;

Assessment criteria

Conditions for passing the Laboratory:
- not exceeding the permissible number of absences;
- isolating a biologically active substance from plant material and developing its characteristics;
- development of a pathway for the synthesis of substances of potential biological importance ;
- carrying out a multi-stage synthesis of a target organic compound;
- preparation of a report summarizing the work carried out during the labs;

Bibliography

1.J Clayden, Organic Chemistry, Oxford University Press 2001
2.A. Vogel, Practical Organic Chemistry, Wiley
3. J. Gawroński, K. Gawrońska, M. Kwit, Współczesna synteza organiczna, PWN
4. L. F. Tietze, T. Eicher, U. Diederichsen, A. Speicher, Reactions and syntheses, WILEY-CH
5. Literature databases:
- Reaxys
- SciFinder
- Scopus

Additional information

Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system:

Description of 1200-2BLOK2L2 in USOSweb