Proteins as molecular targets in drug design 1200-1PMTDDL
A lecture is held in the second half of the semester. A lecture introduces basic information on the main types of proteins which are molecular targets of currently used drugs, with particular emphasis on transmembrane proteins. Among enzymes i.a. kinases and proteases will be presented, among receptors - GPCR receptors and nuclear receptors, among transport proteins - SLC transporters. Additionally, proteins constituting new molecular targets will be presented, e.g. adhesive proteins. The next part of the lecture will be dedicated to biochemical processes corresponding to these proteins. The concept of a signaling and metabolic pathway will be introduced on the example of drugs modulating the activation of GPCR receptors and on the example of antibiotics. The last part of the lecture will be dedicated to the drug design process, taking into account e.g. virtual screening based on either ligand or receptor structure, ADMETox, drug repositioning, drug adverse reactions and pharmacogenomics. The relationship between the chemical structure of the proposed drug and its activity will be also discussed, as well as selectivity and specificity of drugs targeting GPCR receptors.
Estimated student workload per semester: 37.5 hours, including:
- 15 hours - lecture attendance
- 7.5 hours - consultations
- 15 hours - preparation for the final exam
Main fields of studies for MISMaP
physics
biology
computer science
biotechnology
Course dedicated to a programme
Courses
Type of course
elective monographs
Mode
Prerequisites (description)
Course coordinators
Learning outcomes
Students will be able to describe basic types of proteins – targets of modern drugs and describe the corresponding biochemical processes in a basic way. Students will be able to describe the drug design process on selected example and to interpret associated clinical data. Students will be able to explain basic terms related to drug design.
KNOWLEDGE: After completing the course the student knows and understand:
K_W01, K_W02, K_W05, K_W07, K_W08, K_W11
- advanced chemistry and understands the place of chemistry in the system of exact and natural sciences as well as its importance for the development of humanity
- the fundamentals of biochemistry and understands the significance of chemical phenomena in processes occurring in living nature
- in-depth concepts within a selected chemical specialization enabling the use of methods and concepts appropriate for this specialization and allowing independent research work
- the mathematical description of basic chemical phenomena and processes, and is able to explain them independently
- advanced techniques in computational methods appropriate to a given chemical specialization
- current directions in the development of chemistry and the latest scientific discoveries in a given chemical specialization
SKILLS: After completing the course the student is able to:
K_U05, K_U08, K_U11, K_U12, K_U13, K_U14, K_U19
- independently plan and conduct theoretical research within their chemical specialization
- find necessary information in professional literature, databases, and other information sources and competently assess the reliability of obtained information
- discuss the place of chemistry in the system of exact and natural sciences and its importance for the development of civilization
- present, in a way understandable also to non-specialists, the results of the most important discoveries in chemistry and related sciences
- independently acquire knowledge and develop professional skills using various sources (written and electronic), including foreign-language sources
- use patent information resources
- learn independently and define directions for further education
SOCIAL COMPETENCES: After completing the course, the student is ready to:
K_K01, K_K03, K_K05
- continue self-education and independent searching for information in the literature, including foreign-language sources
- correctly identify and resolve dilemmas related to professional practice, both substantive, methodological, organizational, and ethical
- take conscious responsibility for undertaken research initiatives, experiments, or observations
Assessment criteria
A final exam in speaking with at least 50 % is required to pass. It will cover issues discussed during the lecture. Class attendance is required with two possible absences.
Additional information
Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system: