Construction and transformation of organic molecules 1200-1KTMCHOWL

Tools for construction and transformation of molecules:

The formation of carbon-hydrogen bonds: additions to the C = C bonds, addition to the C = O bonds, s stereochemically controlled homogeneous hydrogenation, enantioselective hydrosilylation.
Additions to the C = N bonds, hydrogenation and asymmetric hydrogen transfer of imines, imines hydrosilylation, 1,4-dihydropyridine as reducting agents for imines, oxime ethers, and related compounds.

The formation of carbon-oxygen bonds: the formal addition of an oxygen atom to alkene molecule, Katsuki-Sharpless epoxidation, Jacobsen epoxidation, Julia-Colonna epoxidation of activated alkenes, stereoselective dihydroxylation.
The formation of carbon-nitrogen bonds: stereoselective and tosyloaziridination and aziridination of alkenes.

Additions to olefinic bond: Stereocontrolled addition of HY-type reagents, nucleophilic addition of heteroatoms to olefins, α-functionalization of carbonyl compounds.

The formation of carbon-carbon bonds: alkylation of chiral enolates controlled by activating group, catalytic alkylation of enolates. Stereocontrolled aldol reactions, organokatalysis using amino acid derivatives, ureas, and thioureas. Nucleophilic addition to the carbonyl groups: by carbon sp3, sp2, and sp nucleophiles allyl; propargylation and alkenylation of carbonyl groups, additions of stabilized carbanions, stereoselective cyanosilylation.
Additions to the C = N bonds: Mannich and Strecker reactions, addition of carbon sp3, sp2, and sp nucleophiles.
Coupling reactions catalyzed with π-allyl complexes of transition metals.
Catalytic activation of C-H bonds.
Sigmatropic rearrangements: stereocontrolled Claisen rearrangement, Cope and ene reactions. Enantioselective Stetter reaction. Baylis-Hillman reaction and related processes.
Aromatic electrophilic and nucleophilic substitution. The replacement of hydrogen or other groups in aromatic systems.
The cyclization processes: cycloaddition reactions; Diels-Alder reactions, and hetero-Diels-Alder reactions and their stereochemical control. Enantioselective [3 + 2] cycloaddition, Simmons-Smith cyclopropanation. Complex pseudocyclization processes, multicomponent reactions.
Carbo- and heterocyclization processes: intramolecular Michael addition, Robinson annulation, hydroboration reaction, Pauson-Khand reaction.
Cyclization catalyzed by rhodium complexes. Enantioselective Heck reaction, the Nazarov reaction, Pictet-Spengler cyclization - stereochemical aspects. Enantioselective metathesis processes.