Toxicology 1200-1CHMTOKW6
History of toxicology. Toxicology as a scientific discipline and its development. Basic definitions of toxicology. Poison definition. Groups of poisons and the principles of their classification and labelling. Current legal regulations regarding chemical safety. The relation between poison concentration, duration of exposure to poison and the toxic effect. Characterization of basic factors affecting the toxicity of xenobiotics (dependent on the chemical compound, affected organism and environmental conditions). Toxicodynamics: receptor and non-receptor mechanisms of action on the examples of poisons and the group of substances of toxicological significance (pesticides, metals and metalloides, gases, poisons produced by organisms at al.). Interactions of poisons. Chemical mutagenicity, carcinogenicity, teratogenicity. Genotoxic and epigenetic carcinogens. ADME: absorption, distribution, metabolism and excretion of poisons. Biotransformation processes vs. xenobiotic toxicity. Toxicometrics. Basic principles and scope of regulatory toxicology. Quantitative assessment of exposure to potentially toxic substances. Toxicometric parameters. 3R rules, alternative methods in toxicology.
Estimated student workload during the semester: 75 hours
participation in classes – 30 hours
individual study after each lecture – 15 hours
exam preparation – 20 hours
consultations with the instructor – 10 hours
Main fields of studies for MISMaP
environmental protection
chemistry
Type of course
Prerequisites (description)
Course coordinators
Mode
Learning outcomes
Student:
- knows basic toxicological definitions and dependences;
- knows and understands toxicokinetics and toxicodynamics principles;
- knows and understands the processes of chemical mutagenesis, carcinogenesis and teratogenesis;
- knows the principles of labelling of chemical substances and preparations and their importance in chemical safety.
Knowledge: the graduate knows and understands:
K_W10 – to an advanced extent, the metabolic processes and their chemical mechanisms occurring in the human body, the ways in which they are regulated, and the impact of toxic substances on their functioning.
K_W11 – to an advanced extent, biological knowledge concerning physiological processes and the functioning of organs in the human body, as well as the medical effects of disturbances in the metabolic processes occurring therein. The graduate knows the structure of the cell and the role and function of its basic components.
Bibliography
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Term 2024L:
1. Piotrowski J. (red). Podstawy Toksykologii, Wydawnictwa Naukowo-Techniczne, Warszawa, 2017 (wybrane zagadnienia) |
Term 2025L:
1. Piotrowski J. (red). Podstawy Toksykologii, Wydawnictwa Naukowo-Techniczne, Warszawa, 2017 (wybrane zagadnienia) |
Notes
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Term 2024L:
None |
Term 2025L:
None |
Additional information
Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system: