Drug Chemistry 1200-1CHMCHLW6
Cycle of lectures on Drug Chemistry will have the task introduce the audience with the directions of development this leading discipline among pharmaceutical sciences and present significance currently used drugs in modern pharmacotherapy. When discussing the individual groups of drugs was taken into account: chemical structure and nomenclature, physico-chemical properties important for bioavailability, pharmacological activity, receiving a specific drug form, cellular mechanism of action, relationship between chemical structure and mechanism of action, metabolism and its importance for activity and toxicity of active substances, and interactions between drugs and side effects. Progress and development in medical science about cognition patomechanism of many diseases and molecular mechanism of drug actions led to an introduction to healing a new medicines with a unique mechanism of action with effective in the treatment of diseases. Despite this, there are still many diseases that cannot be cured, and medications only reduce adverse symptoms resulting from a specific medical condition or they delay his progress. It does also concern, among other things, neurodegenerative diseases: Alzheimer and Parkinson diseases as well as cancer. Complete recovery in many diseases is still impossible, and drugs used improve just only quality of life.
In the introductory part of lecture the audience will be introduced to with the breakdown of medicinal substances according to the Anatomical Therapeutic Chemical (ATC) classification system and chemical structure of basic medicinal substances. Molecular targets of drug action ( receptor mechanism, ion channels , enzymes ) will be presented in the part regarding mechanism of action of the drugs in question. Metabolism as integral part inactivation of biological compounds, but simultaneously as a way to activate them will be the subject of another presentation. In the next presentations individual groups of drugs administered in diseases limited to anatomical and functional systems will be discussed. It will be discussed drugs that act on nervous, cardiovascular, respiratory, digestive and immunological system, administered in infectious and neoplastic diseases.
detailed list of topics for individual lectures is presented below:
1. Introduction to Drug Chemistry
a. nomenclature and classification of drugs
b. molecular targets of drugs
2. Stereochemical structure of drugs and activity of medicinal substances
a. Spatial isomerism
b. Structural isomerism
3. Biotransformation of drugs
a. Oxidation reactions
b. Reduction reactions
c. Hydrolysis reactions
d. Coupling reactions
4. Examples of drugs acting on the nervous system
a. Antidepressants
b. Neuroleptics
c. Hypnotics
d. Antiepileptic drugs
e. Analgesics
f. Drugs used in neurodegenerative diseases
5. Drugs used in cardiovascular diseases
a. angiotensin converting enzyme inhibitors
b. beta blockers
c. calcium channel antagonists
d. diuretics
e. antiarrhythmic drugs
f. medications for high blood presure
6. Drugs used in respiratory system diseases
a. Antiasthamtics
b. Expectorant drugs and antitussive drugs
7. Antirheumatic drugs
a. non-steroidal anti-inflammatory drugs
8. Drugs used in diseases of the gastrointestinal tract
a. in gastric and duodenal ulcers
b. in diseases of the liver and biliary tract
c. Antiemetic drugs
d. Anti-diarrhoeal drugs and laxatives
e. Spasmolytic drugs
9. Hormones
10. Drugs for the treatment of diabetes
11. Antihistamines
12. Vitamins
13. Drugs for infectious diseases
a. Mechanism of action
b. Sulfonamides
c. Beta lactam antibiotics
d. Aminoglycoside antibiotics
e. Macrolide antibiotics
f. Anti-tuberculosis drugs and antileprosy medicines
g. Antiviral drugs
14. Anticancer drugs
a. targeted molecular anti-cancer therapy
15. Medication used in autoimmunological diseases. Antisense drugs
Estimated student workload per semester – 75 hours, including:
participation in classes – 30 hours
consultations – 10 hours
exam preparation – 35 hours
Type of course
Prerequisites (description)
Course coordinators
Learning outcomes
The student knows and understands:
K_W08 to an advanced degree the classification of organic compounds into classes corresponding to types of functional groups (nomenclature, structure, chemical reactions, methods of synthesis, occurrence, and applications). The student knows and understands the mechanisms of selected organic reactions and their stereochemical aspects.
K_W10 to an advanced degree metabolic processes and their chemical mechanisms occurring in the human body, the ways in which they are regulated, and the impact of toxic substances on their functioning.
K_W11 to an advanced degree biological knowledge concerning physiological processes and the functioning of organs in the human body, as well as the medical effects of metabolic disorders occurring therein. The student knows the structure of the cell and the role and function of its basic components.
K_W17 to an advanced degree the aspects of drug structure, action, and synthesis, and understands the interdisciplinary nature of designing new drugs and drug delivery systems. The student knows the fundamentals of molecular modeling.
The student is able to:
K_U08 analyze problems in the field of organic chemistry, including investigating the mechanisms of organic reactions.
K_U22 independently acquire knowledge and develop professional skills using various sources (printed and electronic), including those in a foreign language.
The student is ready to:
K_K07 engage in continuous professional development. The student is able to independently search for information in the literature, including in foreign languages.
Assessment criteria
Obligatory attendance at lectures (admissible absence from three lectures). Method of verification learning effect based on results of test exam after the end of lectures. Minimum 60 % correct answers in the test passes the subject.
Practical placement
none
Bibliography
1. D. Steinhilber M, M. Schubert-Zsilavecz, H.J. Roth: Chemia Medyczna; MedPharm Polska 2012
2. O. Achmatowicz: Nomenklatura związków organicznych; Polskie Towarzystwo Chemiczne, Warszawa 1994
3. A. Zejc, M. Gorczyca: Chemia Leków. Podręcznik dla studentów farmacji i farmaceutów, PZWL 2013
4. G.L. Patrick: Chemia organiczna – krótkie wykłady, PWN 2008
5. M. Zając, E. Pawełczyk, A. Jelińska: Chemia Leków AM Poznań2006
6. E. Pawełczyk i wsp.: Chemiczne mechanizmy działania leków.AM Poznań 1995
Additional information
Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system: