Drug Chemistry 1200-1CHMCHLW6

Cycle of lectures on Drug Chemistry will have the task introduce the audience with the directions of development this leading discipline among pharmaceutical sciences and present significance currently used drugs in modern pharmacotherapy. When discussing the individual groups of drugs was taken into account: chemical structure and nomenclature, physico-chemical properties important for bioavailability, pharmacological activity, receiving a specific drug form, cellular mechanism of action, relationship between chemical structure and mechanism of action, metabolism and its importance for activity and toxicity of active substances, and interactions between drugs and side effects. Progress and development in medical science about cognition patomechanism of many diseases and molecular mechanism of drug actions led to an introduction to healing a new medicines with a unique mechanism of action with effective in the treatment of diseases. Despite this, there are still many diseases that cannot be cured, and medications only reduce adverse symptoms resulting from a specific medical condition or they delay his progress. It does also concern, among other things, neurodegenerative diseases: Alzheimer and Parkinson diseases as well as cancer. Complete recovery in many diseases is still impossible, and drugs used improve just only quality of life.
In the introductory part of lecture the audience will be introduced to with the breakdown of medicinal substances according to the Anatomical Therapeutic Chemical (ATC) classification system and chemical structure of basic medicinal substances. Molecular targets of drug action ( receptor mechanism, ion channels , enzymes ) will be presented in the part regarding mechanism of action of the drugs in question. Metabolism as integral part inactivation of biological compounds, but simultaneously as a way to activate them will be the subject of another presentation. In the next presentations individual groups of drugs administered in diseases limited to anatomical and functional systems will be discussed. It will be discussed drugs that act on nervous, cardiovascular, respiratory, digestive and immunological system, administered in infectious and neoplastic diseases.

detailed list of topics for individual lectures is presented below:

1. Introduction to Drug Chemistry
a. nomenclature and classification of drugs
b. molecular targets of drugs
2. Stereochemical structure of drugs and activity of medicinal substances
a. Spatial isomerism
b. Structural isomerism
3. Biotransformation of drugs
a. Oxidation reactions
b. Reduction reactions
c. Hydrolysis reactions
d. Coupling reactions
4. Examples of drugs acting on the nervous system
a. Antidepressants
b. Neuroleptics
c. Hypnotics
d. Antiepileptic drugs
e. Analgesics
f. Drugs used in neurodegenerative diseases
5. Drugs used in cardiovascular diseases
a. angiotensin converting enzyme inhibitors
b. beta blockers
c. calcium channel antagonists
d. diuretics
e. antiarrhythmic drugs
f. medications for high blood presure
6. Drugs used in respiratory system diseases
a. Antiasthamtics
b. Expectorant drugs and antitussive drugs
7. Antirheumatic drugs
a. non-steroidal anti-inflammatory drugs
8. Drugs used in diseases of the gastrointestinal tract
a. in gastric and duodenal ulcers
b. in diseases of the liver and biliary tract
c. Antiemetic drugs
d. Anti-diarrhoeal drugs and laxatives
e. Spasmolytic drugs
9. Hormones
10. Drugs for the treatment of diabetes
11. Antihistamines
12. Vitamins
13. Drugs for infectious diseases
a. Mechanism of action
b. Sulfonamides
c. Beta lactam antibiotics
d. Aminoglycoside antibiotics
e. Macrolide antibiotics
f. Anti-tuberculosis drugs and antileprosy medicines
g. Antiviral drugs
14. Anticancer drugs
a. targeted molecular anti-cancer therapy
15. Medication used in autoimmunological diseases. Antisense drugs