Medical Biochemistry 1200-1CHMBMED4

The relationship between protein function and structure, as exemplified by hemoglobin and collagen. Enzymes - structure, classification, enzymatic reactions and their mechanisms, hyperbolic kinetics, types of inhibition, determination of kinetic parameters, allosteric enzymes, regulation of enzymatic activity. Signal transduction pathways, hormones, membrane receptors: G protein-coupled receptors, tyrosine kinase receptors. Bioenergetics - cellular respiration and oxidative phosphorylation. Carbohydrate metabolism, gluconeogenesis, the tricarboxylic acid cycle, the pentose cycle, glycogen metabolism. Fatty acid biosynthesis and storage, ketogenesis, cholesterol and steroid biosynthesis, lipoproteins, diseases resulting from disorders of carbohydrate and lipid metabolism. Amino acid biosynthesis and degradation, endogenous and exogenous protein metabolism, diseases associated with disorders of amino acid metabolism. Cellular homeostasis.

Total student workload - 120 hours, including:
class participation - 45 hours,
independent study after each lecture and preparation for seminars - 20 hours,
preparation for tests - 20 hours,
preparation for exams - 20 hours,
consultations with the instructor - 15 hours.

Course coordinators

Marzena Jankowska-Anyszka

Type of course

obligatory courses

Mode

Classroom

Requirements

Fundamental Biochemistry and Cytobiochemistry

Prerequisites (description)

Knowledge of the basic characteristics of organisms, the cell location of the basic processes occurring in it, the basic biomolecules present in cells and their properties, the structure and properties of proteins and nucleic acids, and the expression of genetic information.

Learning outcomes

Upon completion of the lecture, the student:
- characterizes the relationships between protein structure and function using selected structural and functional proteins as examples;
- is able to explain enzyme action and various mechanisms of catalysis, as well as apply concepts of enzyme kinetics to describe enzyme activity;
- discusses different mechanisms regulating enzymatic activity, including allosteric regulation and covalent modifications, with reference to key regulatory enzymes;
- is able to describe bioenergetic processes occurring in the cell, in particular cellular respiration and oxidative phosphorylation;
- is able to describe the course and regulation of the main metabolic pathways of carbohydrates, lipids, and amino acids;
- is able to analyze the relationships between metabolic pathways in different physiological and pathological states and apply biochemical knowledge to interpret the causes and consequences of metabolic disorders;
understands the importance of biochemistry in biomedical, biological, and medical sciences.

K_W09: The student knows at an advanced level the chemical components of living organisms, their structural features, chemical properties and their role in biological processes, knows and understands the relationship between the structure of biomolecules and their function.

K_W10: The student knows and understands at an advanced level metabolic processes and their chemical mechanisms occurring in the human body, how they are regulated and the effect of toxic substances on their operation.

K_W11: The student knows and understands at an advanced level biological knowledge in the field of physiological processes and the functioning of organs of the human body and the medical effects of disorders of metabolic processes occurring there. He knows the structure of the cell and the role and operation of the basic structures present in it.

Assessment criteria

Lectures and seminars are obligatory. Acceptable limit of absence is 3 lectures and 1 seminar.
During the seminars or lectures, there will be 4 tests on the material covering the lecture and the seminars. In order to be admitted to the examination, one should gain a minimum 60% of points. In case of receiving a lower number of points, it is necessary to take a written test covering the whole material and obtain a positive mark (min. 60% of the points). In the case of receiving a lower number of points, it is necessary to take a revision test in the revision session. In the case of an unsatisfactory grade from the re-sit examination, the student is not allowed to take the examination.
The final examination in the subject in written form. To obtain a positive mark it is necessary to obtain min. 60% of the points.

Bibliography

1. Biochemistry (Lippincott Illustrated Reviews) Denise S. Ferrier
2. Biochemistry Berg Jeremy M., Stryer Lubert, Tymoczko John L., Gatto Gregory