Bioinorganic Chemistry 1200-1CHBNORWZ
Metal ion complexes in biological systems. Types of metalloproteins: redox, hydrolytic, atom and group transfer enzymes. Activation and transport of dioxygen. Structure of the active site. Mechanism of reversible binding of dioxygen and cooperativity effects. Binding of carbon oxide to myoglobin and hemoglobin. Mechanism of biocatalyzed oxygen reduction. Overview of specific copper and iron enzymes, and their model compounds. Applications: biofuel cells and oxygen sensing. Biological nitrogen cycle: molybdenum-dependent nitrogen fixation, nitrification and denitrification processes. Nitrogenase - enzyme structure and mechanistic studies. Biologically relevant group transfer reactions. Reaction pathways involving cobalamins: vitamin and coenzyme B12. Model systems and role of apoenzyme. Metal ion uptake, transport in organisms and removal. Iron uptake by microorganisms: siderophores. Metal ion concentration gradients (ion-channels, voltage gated channels, ion pumps). Application of metal ion complexes in probing structure of nucleic acid. Medical applications of selected metal complexes: therapeutic compounds, diagnostic agents (MRI), and radionuclide complexes in nuclear medicine
Total student workload:
30h presence on the lectures.
30h preparation to exam
5h getting familiar with the materials provided by lecturer
10h - consultations with the lecturer
Course coordinators
Type of course
Mode
Learning outcomes
After completing the course, the student:
- has an advanced understanding of concepts related to bioinorganic chemistry, including the properties of chemical elements and their biologically important compounds
- understands the fundamentals of processes occurring in living organisms, including the complexation of metal ions by bioligands, enzymatic biocatalysis, photosynthesis, and processes catalyzed by microorganisms
- is able to determine the parameters that govern enzyme activity in the binding and reduction of oxygen, nitrogen, and CO₂
is familiar with the structure of biological membranes and the basics of transport processes across biological and biomimetic membranes
- can explain in a clear and accessible way which metal ions and in what forms are used in medical diagnostics and therapies
- is able to apply the learned laws of chemistry to the analysis of selected problems in bioinorganic chemistry
Programme learning outcomes codes: K_W01, K_W02, K_W04, K_W11, K_U01, K_U08, K_U10, K_U12, K_U13, K_K01
Maximum number of absences: 3
Total student workload: 75 hours, including:
Participation in classes – 30 hours
Preparation for classes and the exam – 35 hours
Consultations with the lecturer – 10 hours
Assessment criteria
Upon agreement with the students: a written or oral student response on several topics covered during the course.
Written form: a test consisting of open-ended questions and single-choice (multiple-choice) questions.
Practical placement
does not concern
Bibliography
Notes from the lectures
For those who would like deeper insight:
Bioinorganic Chemistry R. M. Roat-Malone, Wiley 2007
Podstawy Chemii Bionieorganicznej S. Lippard, M.Berg, PWN 1998
Chemia Bioorganiczna P. Kafarski, B. Lejczak, PWN 1994
Biomolecular Films J.F.Rusling, M. Dekker 2003
(ask the lecturer)