Bioinorganic Chemistry 1200-1CHBNORWZ
Metal ion complexes in biological systems. Types of metalloproteins: redox, hydrolytic, atom and group transfer enzymes. Activation and transport of dioxygen. Structure of the active site. Mechanism of reversible binding of dioxygen and cooperativity effects. Binding of carbon oxide to myoglobin and hemoglobin. Mechanism of biocatalyzed oxygen reduction. Overview of specific copper and iron enzymes, and their model compounds. Applications: biofuel cells and oxygen sensing. Biological nitrogen cycle: molybdenum-dependent nitrogen fixation, nitrification and denitrification processes. Nitrogenase - enzyme structure and mechanistic studies. Biologically relevant group transfer reactions. Reaction pathways involving cobalamins: vitamin and coenzyme B12. Model systems and role of apoenzyme. Metal ion uptake, transport in organisms and removal. Iron uptake by microorganisms: siderophores. Metal ion concentration gradients (ion-channels, voltage gated channels, ion pumps). Application of metal ion complexes in probing structure of nucleic acid. Medical applications of selected metal complexes: therapeutic compounds, diagnostic agents (MRI), and radionuclide complexes in nuclear medicine
Total student workload:
30h presence on the lectures.
30h preparation to exam
5h getting familiar with the materials provided by lecturer
10h - consultations with the lecturer
Type of course
Course coordinators
Mode
Learning outcomes
KNOWLEDGE: Upon completing the course, the student knows and understands:
K_W06, K_W07
To an advanced degree, the concepts and consequences for the course of chemical transformations resulting from the laws of thermodynamics; knows and understands the fundamentals of physical chemistry in the areas of thermodynamics, thermochemistry, electrochemistry, interfacial phenomena, transport processes, and chemical kinetics, including the phenomena of catalysis and biocatalysis.
To an advanced degree, the concepts of inorganic and bioinorganic chemistry, including the properties of chemical elements and their compounds; in particular:
the most important issues and directions of development in bioinorganic chemistry, as well as the significance of progress in this field for humans, their health, and the environment.
SKILLS: Upon completing the course, the student is able to:
K_U01
Apply the acquired laws of chemistry in the analysis of selected chemical and biochemical problems.
SOCIAL COMPETENCES: The student is ready to:
K_K01
Understand and recognize the role of knowledge in formulating opinions and solving problems in the fields of chemistry and biomedical sciences.
Critically assess their own knowledge and skills, as well as evaluate knowledge obtained from various sources.
Assessment criteria
Written or oral reply on a few questions connected with the program of lectures
Practical placement
does not concern
Bibliography
Notes from the lectures
For those who would like deeper insight:
Bioinorganic Chemistry R. M. Roat-Malone, Wiley 2007
Podstawy Chemii Bionieorganicznej S. Lippard, M.Berg, PWN 1998
Chemia Bioorganiczna P. Kafarski, B. Lejczak, PWN 1994
Biomolecular Films J.F.Rusling, M. Dekker 2003
(ask the lecturer)
Additional information
Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system: