Selected problems of molecular biophysics 1100-5BM15

Biophysics is a field of natural science developed in the second second century in the communication of physiologists with the Department of Chemistry at the University of Glasgow. How To Do It: American Physics Richard Feynman "there is no such physics as yoga as yoga, the observers have started to make us make physics out of atoms that we will remove with laws." I was not surprised that it has become biophysics, it has become it has become biophysics, and it has become it has become in the history of development in the development of technology, based on research, on models and methodology, that biography and the development of methodology that biologically, and the biological development of late physics.

One of the most important questions in biophysics is the question of the origin of the phenomenon of life: All life forms are made up of molecules that are not themselves alive. But how are living and inanimate matter different? How could a primitive life form arise from a collection of inanimate particles? So we are dealing with the mystery of the transition from inanimate to living matter. The second, equal is

We also have many issues in molecular biophysics that are not directly related to the above fundamental problems, but are equally interesting, many of which have potential practical applications in medicine or biotechnology. These include the physics of enzymes, mechanisms of molecular recognition, molecular mechanisms of gene expression, mechanisms of intra- and intercellular signaling, the role of acid-base reactions and pH in the course and regulation of molecular intracellular processes, the role of diffusion processes in the course of biomolecular processes, especially those taking place in the cytoplasm, water as an important component of living matter and many others. Issues related to diffusion, the speed of molecular processes, the influence of molecular crowding in the cytoplasm on molecular equilibrium and the speed of molecular processes are examples of problems that constitute an attractive material for calculating exercises.

Main fields of studies for MISMaP

physics

Mode

Classroom

Prerequisites (description)

These classes are intended for students of the Faculty of Physics of the second year of second-cycle studies, specializing in Molecular Biophysics in the field of Application of Physics in Biology and Medicine and in the specialization of Biophysics in the field of Physics. Knowledge of physics and mathematics is assumed in the undergraduate program and the first year of graduate studies. Knowledge of chemistry and biology will also be useful. These classes may also be of interest to MISMaP students in the basic faculties: chemistry and biotechnology.

Course coordinators

Jan Antosiewicz

Learning outcomes

Students will be acquainted with biological phenomena which pose challenges for physicists. They should be able to understand
contemporary scientific literature concerning biological physics and molecular biophysics, and they will be able to get inspiration from
biology for development of their own new research activities.

After completing the course, the student:

KNOWLEDGE

1. Knows the basic laws and concepts of biophysics as well as current ("hot") issues that are dealt with in modern molecular biophysics (KW_01, KW_03).

2. Knows the basic experimental and theoretical methods of biophysics in outline (KW_05).

3. Knows the basic applications of biophysics in biomedical sciences (KW_01).

SKILLS

1. Is able to relate biological observations with their physical and chemical foundations (K_U02).

2. Can choose the right biophysical method to solve a biological problem (K_U05).

SOCIAL COMPETENCE

1. Understands the necessity to systematically supplement and deepen the knowledge of nature (K_K01, K_K05).

2. Understands the value and importance of applying the methodology and concepts in the field of physics in biological sciences (K_K03).

3. Recognizes what is honesty and responsibility in research work (K_K04, K_K06).

Assessment criteria

Written exam in the form of a closed test (30 points) and two tasks to be solved. Attendance at classes is required, both classes devoted to problems solving as well as lectures.

Practical placement

None

Bibliography

1. C. R. Bagshaw, Biomolecular Kinetics, CRC Press, Boca Raton 2017;
2. R. Phillips, J. Kondev, J. Theriot, H. G. Garcia, Physical Biology of the Cell, second ed., Garland Science, London and New York 2013;
3. H. Gutfreund, Kinetics for the life sciences, Cambridge Univ. Press, 1995, Cambridge;
4. L. A. Blumenfeld, A. N. Tikhonov, Biophysical Thermodynamics of Intracellular Processes, Springer-Verlag, 1994, New York;
5. I. N. Serdyuk, N. R. Zaccai, J. Zaccai, Methods in Molecular Biophysics. Structure, Dynamics, Function, Cambridge Univ. Press, Cambridge 2007;

Additional information

Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system:

Description of 1100-5BM15 in USOSweb