Radiobiology 1100-4FM25

Lecture Syllabus:
1. Introduction to Radiobiology and Radiation Physics.
2. Physicochemical Stages of Radiation Action.
3. DNA Damage and Repair Mechanisms.
4. Cell Death and the Cell Cycle.
5/ Radiosensitivity of Tissues and Organs.
6 . Early and Late Radiation Effects.
7. Acute Radiation Syndrome (ARS).
8. Long-term Effects of Radiation.
9. Radiobiological Principles in Radiotherapy.
10. Tumor Microenvironment and Radioresistance.
11. Modern Radiotherapy Techniques.
12. Non-mutagenic and Non-targeted Radiation Effects.
13. Radiobiology of Nuclear Medicine and Diagnostics.
14. Radiation Protection and Safety Standards.

The practical section includes a set of experiments in radiation physics and biology, including:
1. Dosimetry of Radioactive Sources.
2. Cell Survival Assay (Clonogenic Survival Assay).
3. DNA Repair Foci Assay (Immunofluorescence Method).
4. Chromosomal Aberration Assay (Biological Dosimetry).

Primary Literature:
Hall, E. J., & Giaccia, A. J., Radiobiology for the Radiologist (8th ed. or newer), Lippincott Williams & Wilkins.
Janiak, M. K., & Wrembel-Wargocka, J., Radiobiology [Radiobiologia], PWN Scientific Publishers / Medical Publishers.
Breguła, U., et al., Radiation Protection in Medicine [Ochrona radiologiczna w medycynie], PWN Scientific Publishers.

Supplementary Literature:
Joiner, M., & van der Kogel, A., Basic Clinical Radiobiology, CRC Press.
ICRP Publication 103, The 2007 Recommendations of the International Commission on Radiological Protection.
Selected articles from scientific journals: International Journal of Radiation Biology, Radiotherapy and Oncology.

Course completion is based on the results of the final exam and laboratory reports.